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彭敏博士在免疫代謝和營養(yǎng)信號轉(zhuǎn)導(dǎo)方面進(jìn)行了深入的研究，發(fā)現(xiàn)多種調(diào)控營養(yǎng)信號轉(zhuǎn)導(dǎo)的關(guān)鍵分子以及代謝通路調(diào)控免疫細(xì)胞分化的分子機(jī)制，相關(guān)研究成果發(fā)表在cell、nature及science等國際學(xué)術(shù)期刊，并獲得“求是”杰出青年學(xué)者獎(jiǎng)。目前，彭敏博士致力于使用高通量功能基因組學(xué)技術(shù)系統(tǒng)性地研究t淋巴細(xì)胞增殖分化的調(diào)控機(jī)理以及細(xì)胞代謝調(diào)節(jié)免疫應(yīng)答等的分子機(jī)制，并利用這些分子機(jī)理為免疫相關(guān)疾病的診斷和治療提供新策略和新靶點(diǎn)。

實(shí)驗(yàn)室研究方向：

t cells play essential roles in immune response. we are studying t cells with two directions:

1. functional genomics in primary t cells

we are applying genome-wide crispr/cas9 screen in primary t cell in vivo to answer fundamental questions in t cell biology, including development, activation, proliferation and differentiation, as well as t cell fitness (e.g. exhaustion) in tumor microenvironment. identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. mechanisms of metabolic regulation of t cells

metabolic reprogramming is a hallmark of t cell activation, but how metabolic pathways regulate t cell function remains poorly understood. we are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation t cell, and try to target metabolism to treat immune-related diseases.

參考文獻(xiàn)：

1. hanfei zhao, ying liu, lixia wang, gang jin, xiaocui zhao, jing xu, guangyue zhang, yuying ma, na yin, min peng. genome-wide fitness gene identification reveals roquin as a potent suppressor of cd8 t cell expansion and anti-tumor immunity. cell reports. 2021 dec 7;37(10):110083.

2. ke xu*, na yin*, min peng, efstathios g stamatiades, sagar chhangawala, amy shyu, peng li, xian zhang, mytrang h do, kristelle j capistrano, chun chou, christina s leslie, ming o li. glycolytic atp fuels phosphoinositide 3-kinase signaling to support effector t helper 17 cell responses. immunity. 2021. 54(5):976-87.

3. ke xu, na yin, min peng, efstathios g stamatiades, amy shyu, peng li, xian zhang, mytrang h do, zhaoquan wang, kristelle j capistrano, chun chou, andrew g levine, alexander y rudensky, ming o li. glycolysis fuels phosphoinositide 3-kinase signaling to bolster t cell immunity. science. 2021.371(6527):405-10.

4. min peng*, na yin*, sagar chhangawala, ke xu, christina s. leslie, ming o. li. aerobic glycolysis promotes t helper 1 cell differentiation through an epigenetic mechanism. science. 2016 oct 28; 354(6311): 481-484.

preview in science, 2016 oct 28; 354(6311): 419-420. “warburg meets epigenetics”.

preview in dev cell, 2016 november 7;39: 286-287. “metabolic control of cellular differentiation”.

preview in cell metab, 2016 november 8; 24: 651-652. “metabolic signaling drives ifn-g”.

5. min peng, na yin, ming o. li. szt2 dictates gator control of mtorc1 signaling. nature. 2017 mar 16;543(7645):433-437.

6. min peng, na yin, ming o. li. sestrins function as guanine nucleotide dissociation inhibitors for rag gtpases to control mtorc1 signaling. cell. 2014 sep 25; 159(1): 122-33.

博士后招聘

car-t腫瘤治療方向2名：

應(yīng)聘條件：具有免疫學(xué)、分子和細(xì)胞生物學(xué)相關(guān)專業(yè)博士學(xué)位，獲得博士學(xué)位2年以內(nèi)；近期以第一作者身份在國際知名學(xué)術(shù)期刊發(fā)表研究論文，符合清華大學(xué)博士后入站標(biāo)準(zhǔn)；熱愛科研工作，責(zé)任心強(qiáng)，具備團(tuán)隊(duì)合作精神；具備較好的英語溝通、閱讀和寫作能力。

崗位待遇：崗位待遇按照清華大學(xué)相關(guān)規(guī)定執(zhí)行。課題組將根據(jù)工作情況提供一定生活補(bǔ)助和績效獎(jiǎng)勵(lì)。另外，根據(jù)本單位相關(guān)規(guī)定，博士后以第一作者、清華大學(xué)為第一單位發(fā)表高水平學(xué)術(shù)期刊可獲得有非常有競爭力的績效獎(jiǎng)勵(lì)（）。

申請方式：將簡歷（包括學(xué)歷和論文發(fā)表情況）、研究自述（研究興趣、成果以及未來職業(yè)規(guī)劃）、及2-3名推薦人的聯(lián)系方式發(fā)至：；主題標(biāo)明“姓名+應(yīng)聘博士后+高校人才網(wǎng)“。

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